Glossary of peptide terminology (revision 6)
Old revision·19:34, 20 Sep 2024·DrTitration
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| Glossary of peptide terminology | |
|---|---|
| Scope | Terms used across this wiki |
| Arrangement | By domain, then alphabetically |
| List infobox · conventions | |
This glossary defines terms used across PeptidePedia Wiki. Each entry gives a short definition and, where a full article exists, links to it. Terms are grouped by domain and ordered alphabetically within each group.[1]
Definitions here are deliberately brief. Where a term carries a distinction that matters — purity against content, sterility against endotoxin freedom, contraindication against warning — the entry states the distinction and the article develops it.[2]
The glossary is not a substitute for the articles and does not attempt completeness.[3]
Chemistry and manufacture
[edit]- Aib
- α-aminoisobutyric acid, a non-proteinogenic residue used to block DPP-4 cleavage.
- Acylation
- Attachment of a fatty acid to a peptide, usually for albumin binding.
- Crude
- The material obtained directly after cleavage, before purification. See Crude peptide.
- Deletion sequence
- A synthesis by-product missing one or more residues.
- Fmoc
- The base-labile temporary protecting group scheme dominating peptide synthesis.
- Linker
- The resin attachment defining the C-terminal functionality of the finished peptide.
- Lyophilisation
- Freeze-drying; the isolation step producing the powder in a vial. See Lyophilisation.
- SPPS
- Assembly of a peptide on an insoluble support.
- TFA salt
- The salt form in which most reverse-phase-purified peptides are isolated.[1]
References
- ^ a b United States Pharmacopeia, General Chapter <1503>, Quality Attributes of Synthetic Peptide Drug Substances.
- ^ United States Pharmacopeia, General Chapter <621>, Chromatography.
- ^ PeptidePedia Wiki community test-report tally, 2024–2026 (self-reported; see Project:Sourcing guidelines).