GLP-1 receptor agonist: difference between revisions
Diff·revision 12 → 13·00:26, 21 Oct 2024
Difference between revision 12 and revision 13 of GLP-1 receptor agonist. 2 lines changed; the page grew by 187 bytes.
| Revision 12 — 18:54, 6 Oct 2024 EndpointEnid (talk) correct the molar mass — source gives the free-base figure, we had the salt 6,120 bytes +584 | Revision 13 — 00:26, 21 Oct 2024 LOD_Lorcan (talk) expand §Molecular strategies for half-life extension 6,307 bytes +187 | ||
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| 1 | {{Infobox concept | 1 | {{Infobox concept |
| 2 | | name = GLP-1 receptor agonist | 2 | | name = GLP-1 receptor agonist |
| + | 3 | | subtitle = Drug class | |
| 3 | | image = receptor.svg | 4 | | image = receptor.svg |
| 4 | | caption = Class B G-protein-coupled receptor engagement by an acylated peptide agonist. | 5 | | caption = Class B G-protein-coupled receptor engagement by an acylated peptide agonist. |
| ⋮ | ⋮ | ||
| 12 | | Small molecule = [[Orforglipron]] (investigational) | 13 | | Small molecule = [[Orforglipron]] (investigational) |
| 13 | }} | 14 | }} |
| + | 15 | {{hatnote|For the endogenous hormone, see [[Glucagon-like peptide-1]]. For agonists acting at more than one incretin receptor, see [[Dual incretin agonist]].}} | |
| 14 | 16 | ||
| 15 | A '''GLP-1 receptor agonist''' ('''GLP-1 RA''') is a drug that activates the [[GLP-1 receptor]], reproducing and prolonging the actions of the endogenous incretin hormone [[Glucagon-like peptide-1]]. The class was developed for type 2 diabetes and has since been approved, for several of its members, for the treatment of obesity and for reduction of cardiovascular risk.{{r|drucker2018}} | 17 | A '''GLP-1 receptor agonist''' ('''GLP-1 RA''') is a drug that activates the [[GLP-1 receptor]], reproducing and prolonging the actions of the endogenous incretin hormone [[Glucagon-like peptide-1]]. The class was developed for type 2 diabetes and has since been approved, for several of its members, for the treatment of obesity and for reduction of cardiovascular risk.{{r|drucker2018}} |