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Fasting insulin (revision 1)

Old revision·09:00, 14 Sep 2024·UnitsUrsula

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Fasting insulin
SpecimenFasting plasma or serum
InterpretableOnly alongside a simultaneous glucose
StandardisationPoor between assays
Topic infobox · conventions

Fasting insulin is the concentration of insulin measured after an overnight fast. It is widely available and widely over-interpreted: an insulin value alone answers no question, because the same concentration means different things at different glucose concentrations.[1]

Insulin immunoassays are poorly standardised between manufacturers, differing in cross-reactivity with proinsulin and its split products. Values from different laboratories are not interchangeable, and derived indices inherit the discrepancy.[1]

References

  1. ^ a b Wallace TM, Levy JC, Matthews DR. "Use and abuse of HOMA modeling." Diabetes Care 27(6):1487–1495 (2004). DOI:10.2337/diacare.27.6.1487. PMID 15161807.