Fasting insulin: difference between revisions
Diff·revision 2 → 3·15:27, 25 Sep 2024
Difference between revision 2 and revision 3 of Fasting insulin. 5 lines changed; the page grew by 601 bytes.
| Revision 2 — 22:46, 21 Sep 2024 A1c_Alder (talk) give the coefficient of variation with the level it was measured at 1,061 bytes ±0 | Revision 3 — 15:27, 25 Sep 2024 GIP_Genoveva (talk) state whether the figure is a mean or a median 1,662 bytes +601 | ||
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| 10 | Insulin immunoassays are poorly standardised between manufacturers, differing in cross-reactivity with proinsulin and its split products. Values from different laboratories are not interchangeable, and derived indices inherit the discrepancy.{{r|wallace2004}} | 10 | Insulin immunoassays are poorly standardised between manufacturers, differing in cross-reactivity with proinsulin and its split products. Values from different laboratories are not interchangeable, and derived indices inherit the discrepancy.{{r|wallace2004}} |
| 11 | 11 | ||
| + | 12 | == Why it needs glucose alongside it == | |
| + | 13 | Insulin secretion is a response to glucose. A high fasting insulin with a normal fasting glucose indicates that normal glucose is being maintained at the cost of high insulin — the signature of insulin resistance with preserved secretion. The same insulin with a high glucose indicates resistance with inadequate compensation.{{r|wallace2004}} | |
| + | 14 | ||
| + | 15 | A low insulin with a high glucose indicates secretory failure. A low insulin with a normal glucose is unremarkable. The four combinations mean four different things, and only two values together distinguish them. | |
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| 12 | == References == | 17 | == References == |
| 13 | {{reflist}} | 18 | {{reflist}} |