Counterfeit peptide: difference between revisions
Diff·revision 6 → 7·01:01, 16 Jan 2025
Difference between revision 6 and revision 7 of Counterfeit peptide. 3 lines changed; the page grew by 411 bytes.
| Revision 6 — 23:34, 9 Jan 2025 VerifyFirstVida (talk) clarify that a QR code on a certificate proves issuance, not content 2,322 bytes +256 | Revision 7 — 01:01, 16 Jan 2025 BiliaryBea (talk) add the note that self-submitted reports are a self-selected sample 2,733 bytes +411 | ||
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| 18 | Identity determination is the remedy and is not expensive relative to the purchase. A mass determination compares the observed molecular mass with the calculated one; agreement to within a few daltons excludes most substitutions outright. It does not exclude an isobaric substitution — a different molecule of the same mass — for which sequence-level confirmation is required. | 18 | Identity determination is the remedy and is not expensive relative to the purchase. A mass determination compares the observed molecular mass with the calculated one; agreement to within a few daltons excludes most substitutions outright. It does not exclude an isobaric substitution — a different molecule of the same mass — for which sequence-level confirmation is required. |
| 19 | 19 | ||
| + | 20 | The confounding case is a peptide of similar mass in the same family. Analogues within the incretin class differ by hundreds of daltons and are readily distinguished; a deletion sequence of the intended peptide differs by a single residue and is a synthesis defect rather than a counterfeit, though the analytical challenge is comparable. See [[Analytical method validation]]. | |
| + | 21 | ||
| 20 | == References == | 22 | == References == |
| 21 | {{reflist}} | 23 | {{reflist}} |
| ⋮ | ⋮ | ||
| 26 | [[Category:Quality failures]] | 28 | [[Category:Quality failures]] |
| 27 | [[Category:Supply chain integrity]] | 29 | [[Category:Supply chain integrity]] |
| + | 30 | [[Category:Quality and testing]] | |
| 28 | 31 |