Cold chain: difference between revisions
Diff·revision 57 → 58·10:21, 8 Jun 2025
Difference between revision 57 and revision 58 of Cold chain. 7 lines changed; the page grew by 993 bytes.
| Revision 57 — 13:17, 30 May 2025 SupplyWatchSuri (talk) copyedit 21,309 bytes ±0 | Revision 58 — 10:21, 8 Jun 2025 SupplyWatchSuri (talk) expand §Distribution outside regulated channels 22,302 bytes +993 | ||
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| 134 | '''Domestic storage.''' Studies of domestic refrigerators used to store insulin and vaccines have repeatedly found substantial fractions operating outside 2–8 °C, with excursions in both directions and with door shelves warmer and rear walls colder than the compartment average.{{r|hanson2017}} | 134 | '''Domestic storage.''' Studies of domestic refrigerators used to store insulin and vaccines have repeatedly found substantial fractions operating outside 2–8 °C, with excursions in both directions and with door shelves warmer and rear walls colder than the compartment average.{{r|hanson2017}} |
| 135 | 135 | ||
| + | 136 | == Distribution outside regulated channels == | |
| + | 137 | A substantial proportion of the material discussed on this wiki moves outside pharmaceutical distribution, and the cold-chain concept applies to it only partially. The differences are structural rather than incidental. | |
| + | 138 | ||
| + | 139 | There is generally no temperature record. Parcels move by ordinary post or courier without loggers, and no party undertakes to maintain a condition. Where a supplier states a storage requirement, it is a recommendation for the recipient rather than a specification the shipment was managed against. | |
| + | 140 | ||
| + | 141 | The product is generally lyophilised, which changes the physics substantially. A dry amorphous solid held below its glass transition temperature degrades orders of magnitude more slowly than the same peptide in solution, and its temperature sensitivity is correspondingly lower. This is the physical basis on which ambient shipment of dry peptide is defensible, and it is set out in detail at [[Lyophilisation]].{{r|ich_q1a}} | |
| + | 142 | ||
| 136 | == References == | 143 | == References == |
| 137 | {{reflist}} | 144 | {{reflist}} |