C-peptide (revision 11)
Old revision·17:41, 17 Jan 2025·DrTitration
| C-peptideLaboratory medicine | |
|---|---|
| Origin | Connecting peptide of proinsulin |
| Secretion | Equimolar with insulin |
| Hepatic extraction | Negligible |
| Clearance | Renal |
| Topic infobox · conventions | |
C-peptide is the connecting peptide excised from proinsulin during processing and secreted from the beta cell in equimolar quantity with insulin. Because it is not appreciably extracted by the liver, its peripheral concentration reflects secretion more faithfully than insulin does.[1]
Insulin undergoes variable first-pass hepatic extraction of 40–80%, so peripheral insulin understates secretion by an amount that differs between people and with pulsatility. C-peptide avoids this and is the analyte used in any rigorous assessment of beta-cell function.[1]
Its principal limitation is renal: C-peptide is cleared by the kidney, so concentrations rise in renal impairment independently of secretion, and interpretation in that setting requires care.[2]
Use in assessment
[edit]Deconvolution of a peripheral C-peptide profile using known kinetics yields a secretion rate, which is the reference approach for quantifying insulin secretion.[3] It requires timed sampling and modelling and is a research technique.[1]
Simpler indices are used clinically. A fasting C-peptide with a simultaneous glucose distinguishes states of insulin deficiency from insulin resistance; a stimulated C-peptide after a mixed meal or glucagon assesses residual secretory capacity.
The most common clinical use is classification: a very low C-peptide with hyperglycaemia indicates insulin deficiency, while a normal or high value with hyperglycaemia indicates resistance with preserved secretion. The thresholds are assay- and context-dependent.[1]
Interpretation caveats
[edit]| Situation | Effect on C-peptide |
|---|---|
| Renal impairment | Raised, independent of secretion |
| Fasting versus stimulated | Different questions; not interchangeable |
| Exogenous insulin | Suppresses endogenous secretion, lowering C-peptide |
| Assay differences | Between-method variation is substantial |
The exogenous insulin row is the basis of one of the analyte's forensic uses: insulin administered from outside raises insulin while suppressing C-peptide, a pattern that endogenous hypersecretion does not produce.[1]
See also
References
- ^ a b c d e Jones AG, Hattersley AT. "The clinical utility of C-peptide measurement in the care of patients with diabetes." Diabetic Medicine 30(7):803–817 (2013). DOI:10.1111/dme.12159. PMID 23413806.
- ^ American Diabetes Association. "Standards of Care in Diabetes." Diabetes Care 47(Suppl 1) (2024).
- ^ Rorsman P, Braun M. "Regulation of insulin secretion in human pancreatic islets." Annual Review of Physiology 75:155–179 (2013). PMID 22974438.