Bacteriostatic water: difference between revisions
Diff·revision 10 → 11·08:27, 29 Nov 2024
Difference between revision 10 and revision 11 of Bacteriostatic water. 5 lines changed; the page grew by 607 bytes.
| Revision 10 — 10:08, 8 Nov 2024 Retention_Time_Rae (talk) state that reconstituted material should not be frozen, with the source 2,831 bytes +24 | Revision 11 — 08:27, 29 Nov 2024 TitrationTheo (talk) move a stray full stop inside the reference 3,438 bytes +607 | ||
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| 20 | The preservative also does nothing about chemical degradation. A preserved solution remains subject to [[Deamidation|deamidation]], oxidation and [[Peptide aggregation|aggregation]], and the presence of a preservative does not extend chemical stability at all.{{r|manning2010}} | 20 | The preservative also does nothing about chemical degradation. A preserved solution remains subject to [[Deamidation|deamidation]], oxidation and [[Peptide aggregation|aggregation]], and the presence of a preservative does not extend chemical stability at all.{{r|manning2010}} |
| 21 | 21 | ||
| + | 22 | == Interaction with peptides == | |
| + | 23 | Benzyl alcohol is a small amphiphile and can promote aggregation in some proteins and peptides, an effect documented in the biopharmaceutical literature for several molecules. Whether a given peptide is affected is molecule-specific and is established experimentally.{{r|manning2010}} | |
| + | 24 | ||
| + | 25 | This is the reason preserved and unpreserved presentations of the same active substance exist. Where a molecule is preservative-sensitive, single-entry containers with unpreserved diluent are used, and the container is discarded after one withdrawal rather than dated for repeated entry. | |
| + | 26 | ||
| 22 | == References == | 27 | == References == |
| 23 | {{reflist}} | 28 | {{reflist}} |