Arcuate nucleus: difference between revisions
Diff·revision 2 → 3·11:02, 1 Oct 2024
Difference between revision 2 and revision 3 of Arcuate nucleus. 7 lines changed; the page grew by 1,076 bytes.
| Revision 2 — 12:24, 19 Sep 2024 AmylinAmos (talk) add a figure for the secretion time course and caption it 1,271 bytes ±0 | Revision 3 — 11:02, 1 Oct 2024 MolarMassMaeve (talk) fix hyphenation per PP:MOS 2,347 bytes +1,076 | ||
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| 10 | Its position adjacent to the median eminence, where the capillaries are fenestrated, gives it unusual access to circulating signals. Hormones that cannot cross an intact blood-brain barrier can nonetheless influence arcuate neurons, which is why the nucleus is a principal target for peripherally administered peptides including [[GLP-1 receptor agonist|GLP-1 receptor agonists]].{{r|schwartz2000}} | 10 | Its position adjacent to the median eminence, where the capillaries are fenestrated, gives it unusual access to circulating signals. Hormones that cannot cross an intact blood-brain barrier can nonetheless influence arcuate neurons, which is why the nucleus is a principal target for peripherally administered peptides including [[GLP-1 receptor agonist|GLP-1 receptor agonists]].{{r|schwartz2000}} |
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| + | 12 | == Neuronal populations == | |
| + | 13 | POMC neurons synthesise a precursor that is cleaved to α-melanocyte-stimulating hormone and other products. Released α-MSH acts at melanocortin-3 and melanocortin-4 receptors on downstream neurons to suppress food intake. These neurons are activated by leptin, insulin and [[Glucagon-like peptide-1|GLP-1]] receptor signalling.{{r|cone2005,woods2009}} | |
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| + | 15 | AgRP/NPY neurons are activated by fasting and by ghrelin, and inhibited by leptin. AgRP is an inverse agonist at melanocortin-4 receptors — it does not merely block α-MSH but reduces constitutive receptor signalling below baseline — and NPY acts at its own receptors to promote feeding. The two populations also inhibit each other directly. | |
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| 12 | == References == | 17 | == References == |
| 13 | {{reflist}} | 18 | {{reflist}} |
| 14 | <ref name="schwartz2000">Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG. "Central nervous system control of food intake." ''Nature'' 404(6778):661–671 (2000). PMID 10766253.</ref> | 19 | <ref name="schwartz2000">Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG. "Central nervous system control of food intake." ''Nature'' 404(6778):661–671 (2000). PMID 10766253.</ref> |
| + | 20 | <ref name="cone2005">Cone RD. "Anatomy and regulation of the central melanocortin system." ''Nature Neuroscience'' 8(5):571–578 (2005). DOI:10.1038/nn1455. PMID 15856065.</ref> | |
| + | 21 | <ref name="woods2009">Woods SC. "The control of food intake: behavioral versus molecular perspectives." ''Cell Metabolism'' 9(6):489–498 (2009). PMID 19490904.</ref> | |
| 15 | 22 | ||
| 16 | {{DEFAULTSORT:Arcuate nucleus}} | 23 | {{DEFAULTSORT:Arcuate nucleus}} |