Arcuate nucleus: difference between revisions
Diff·revision 11 → 12·19:45, 21 Feb 2025
Difference between revision 11 and revision 12 of Arcuate nucleus. 3 lines changed; the page grew by 447 bytes.
| Revision 11 — 18:12, 1 Feb 2025 ProglucagonPia (talk) rm the causal claim about appetite — the cited work is associative 3,874 bytes +101 | Revision 12 — 19:45, 21 Feb 2025 LCellLeif (talk) move the trial material out of §Physiology into the compound articles 4,321 bytes +447 | ||
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| 25 | This is the mechanistic basis for the central action of peripherally injected peptides that are far too large to cross the barrier elsewhere. It also explains why the area postrema, another circumventricular organ, is the site of the nausea produced by the same agents. | 25 | This is the mechanistic basis for the central action of peripherally injected peptides that are far too large to cross the barrier elsewhere. It also explains why the area postrema, another circumventricular organ, is the site of the nausea produced by the same agents. |
| 26 | 26 | ||
| + | 27 | Whether a given peptide agonist acts principally at the arcuate, at the brainstem, or through vagal afferents differs between molecules and doses, and the relative contributions in humans are inferred from animal work rather than measured directly.{{r|drucker2018}} | |
| + | 28 | ||
| 27 | == References == | 29 | == References == |
| 28 | {{reflist}} | 30 | {{reflist}} |
| 29 | <ref name="schwartz2000">Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG. "Central nervous system control of food intake." ''Nature'' 404(6778):661–671 (2000). PMID 10766253.</ref> | 31 | <ref name="schwartz2000">Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG. "Central nervous system control of food intake." ''Nature'' 404(6778):661–671 (2000). PMID 10766253.</ref> |
| 30 | <ref name="cone2005">Cone RD. "Anatomy and regulation of the central melanocortin system." ''Nature Neuroscience'' 8(5):571–578 (2005). DOI:10.1038/nn1455. PMID 15856065.</ref> | 32 | <ref name="cone2005">Cone RD. "Anatomy and regulation of the central melanocortin system." ''Nature Neuroscience'' 8(5):571–578 (2005). DOI:10.1038/nn1455. PMID 15856065.</ref> |
| + | 33 | <ref name="drucker2018">Drucker DJ. "Mechanisms of action and therapeutic application of glucagon-like peptide-1." ''Cell Metabolism'' 27(4):740–756 (2018). PMID 29617641.</ref> | |
| 31 | <ref name="woods2009">Woods SC. "The control of food intake: behavioral versus molecular perspectives." ''Cell Metabolism'' 9(6):489–498 (2009). PMID 19490904.</ref> | 34 | <ref name="woods2009">Woods SC. "The control of food intake: behavioral versus molecular perspectives." ''Cell Metabolism'' 9(6):489–498 (2009). PMID 19490904.</ref> |
| 32 | 35 |